WOW! Junk DNA as a metaphor! We have arrived!

In an article in The New Republic about how Republicans are being disingenous by opposing the health care bill on account of its length, Harold Pollack writes:

Most of the junk DNA of the Senate bill is the usual block-and-tackle of complicated legislation, and is of no particular ideological or partisan concern. Many of the Senate bill’s 2,000 pages concern proposed delivery reforms and other measures that are widely supported by policy wonks across the political spectrum, including those in the recently-departed Bush administration. There’s a lot of complex detail to get right.

I am so proud.
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We must act now to stop the 2020 metaphors

As we enter the 2010’s a horrible spectre is before us – the year 2020 and the inevitable sickening overuse of 2020 vision/2020 hindsight in articles about the decade. We are seeing it already.

Human nature being what it is, I can’t imagine we’re going to actually be able to convince journalists, bloggers and common folk to avoid using an obvious, easy and cheesy metaphor. But I have come up with a solution – and I am hoping you will all join me on this crusade.

We have to change the scale used for visual acuity. The 20’s in 20/20 refer to the distance at which the person in question (numerator) and average person (denominator) can distinguish two objects in a standard visual test. Thus 20/40 is worse than average, 20/10 better. But there’s not a compelling reason to express these results this way – indeed many countries use a straight decimal scale where 20/20 = 1.0 (20/40 = 0.5; 20/10 = 2.0). In many ways this makes more sense. And if we can make the change quickly, we can save ourselves from the 2020 metaphors.

Please join me! I’ll be outside the Berkeley Eye Clinic on the 20th of every month.

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Thoughts on the Berkeley protests

I’ve made no secret of my opposition to this week’s protests at Berkeley and other UC campuses. The tactics were stale, the targets were wrong, and the rhetoric was ineffective. But that doesn’t mean that I don’t think what’s going on at UC doesn’t completely suck.

The immediate cause of the protests was the 32% tuition increase instituted last week by the regents. While a UC education remains a bargain – the ~$2,500 increase in annual tuition brings the total to around $10,000 – the extra cost will be a crushing burden for many students.

But it doesn’t really matter whether you view $10,000 as unreasonably high or a great deal. The real problem with the tuition increase is what is says about the UC’s – and Berkeley in particular – status as a public institution.

Berkeley became what it is today – the best public university in the world – because the state lavished money on it – not only to subsidize student tuition (which, until Reagan was governor, was effectively free) but also to build the research facilities, museums, libraries and other trappings of an elite university and to recruit the best faculty to fill them.

And, as students are being asked to pick up a larger share of the budget, the university’s financial crisis is driving researchers, curators, etc… who have long relied on state support to adopt more of a private fundraising model. And in doing so, Berkeley is becoming more and more like every other place. And while that doesn’t necessarily mean it will stop being an elite university, it does mean it will stop being the special place it currently is.

I also want to say something about the Berkeley protesters fingering of UC president Yudof and Berkeley  chancellor Birgeneau as the culprits. I think this is absurd. Given the state of the university’s budget, they’ve really had no choice but the slash salaries, lay off workers and raise tuition. And the idea that the administration is somehow sitting on huge pots of money that they’re not spending because they want to hasten the transition to a private institution model (something a lot of protesters were arguing) is absurd.

Everything I’ve read and heard suggests that Yudof has done his best to argue our case in Sacramento. And it’s not clear that anything would have changed enough minds to make a difference. But, as we constantly tell our students, it doesn’t matter how hard you try on the test – you have to succeed. And there’s no doubt that UCs administration has failed to defend the university against the brutal cuts it has, of late, absorbed. Someone has to be held accountable for this failure.

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Why I don’t support the UC faculty walkout

I sent this letter to some colleagues who are supporting the proposed UC faculty walkout on September 24th.

I want to thank you and the others who are spending their time and energy trying to figure out how to deal with challenges of the UC budget. I understand the appeal and value of a collective expression of disgust from the UC faculty, staff and students. But as loathsome as I find the budget cuts and as concerned as I am about the future of the UC system, the framing of this issue as being a battle between UC faculty and Yudof/UCOP is so misplaced and wildly counterproductive that there is no way I can support it.

While I am far from agreeing with everything Yudof has done, or the way he has done it, the clear culprit here is declining public financial support for the UC system. One of the main reasons we keep on absorbing these cuts – and why many have become permanent – is the sense amongst many that the University is rich, and doesn’t need this money. So the implication from SAVE and others that somehow the furloughs and other cuts were discretionary actions taken by UCOP is not only absurd, but plays right into the hands of people who want to cut the budgets even more.

I agree that a major part of the problem is that people on the outside of UC don’t realize how devastating these cuts are to the system, and how they threaten our role as the premier public institution in the nation. We should be doing everything in our powers to educate the public, and our students, about these issues.

Unfortunately, whether intentional or not, the walkout and assocaited actions have become a platform for firing invectives at Yudof or rallying for faculty self-governance – which, while important, is not the most important thing right now. It makes us seem shrill and self-serving, and does not advance what should be our main objective – directing a positive appeal to the taxpayers of California to renew their support for UC.

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DNA testing in baseball – more silly alarmism from reporters and bioethicists

The New York Times is fronting a story that combines two of my favorite subjects – DNA and baseball. Unfortunately, the story is ridiculously alarmist, and either willfully or ignorantly conflates DNA paternity/maternity tests with tests designed to extract other information from a person’s genome.

The plug for the piece is that Major League Baseball has apparently used DNA tests to establish the parentage of a few prospects in the Dominican Republic – a step they have taken to counter efforts by some players to assume a younger person’s identity to make them more appealing to major league organizations. This part of the story is straightforward – before plopping down several hundred thousand, or million, dollars on a 16 year old phenom, MLB clubs want to make sure they’re getting what they’re paying for.

But not content to simply report on an effort to address a problem that has plagued baseball for the last decade (and, it is important to note, has made clubs less willing to take risks on young Dominican players, thus hurting the kids who don’t cheat) the NYT plays the spooky DNA bogeyman card:

“DNA contains a host of information about risks for future diseases that prospective employers might be interested in discovering and considering,” said Kathy Hudson, the director of the Genetics and Public Policy Center and an associate professor at Johns Hopkins University.

Yes, DNA does contain that information. But as Hudson knows full well, the DNA tests used to establish paternity/maternity test a small number of markers simply to establish whether a person is another person’s offspring – they do not look at markers used to predict disease risk, athletic abilities, or any other phenotype.

Now, of course,  MLB teams could choose to carry out such tests. And a scout raises some interesting questions:

…I know they’re looking into trying to figure out susceptibility to injuries, things like that. If they come up with a test that shows someone’s connective tissue is at a high risk of not holding up, can that be used? I don’t know. I do think that’s where this is headed.

Exploring these issues would make a good story. And I think it’s inevitable that this is going to happen unless it is specifically outlawed (and I’m not sure GINA really does that). But it’s absurd to imply that using DNA to establish that people are accurately reporting the parentage is equivalent to  demanding that players undergo extensive genetic screening for inherited conditions that might affect their baseball future.

It’s just another example of bioethicists and the media squawking thoughtlessly about the sinister things that DNA can do without even trying to put it in any kind of context.

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Letter to the editor in Science

Science 17 July 2009:
Vol. 325. no. 5938, p. 266
DOI: 10.1126/science.325_266c

Letters
Open Access: The Sooner the Better
In the Brevia “Open access and global participation in science” (20 February, p. 1025), J. A. Evans and J. Reimer argue that a research article published online is only modestly (8%) more likely to be cited if it is freely available. This result would seem to cast doubt on one important argument in favor of free access—that it will increase the visibility of a paper to colleagues.

However, the 8% statistic that Evans and Reimer highlight is misleading. The authors’ supporting online material (figure S1C) clearly shows that the impact of free access on citations is heavily dependent on the age of the article at the time free access was provided. In particular, when articles were made freely available within 2 years of publication, their citations increased by almost 20%.

This far more dramatic effect is the one scientists and journals should consider when deciding when to provide free access. If this decision is to be made purely on the basis of citation impact, the upward trend of the curve in figure S1C argues strongly in favor of minimal delays.

Unfortunately, it is hard to tell exactly how short a delay the data support, because the underlying citation information is not provided. That the raw data for such a provocative paper is unavailable is an astonishing violation of the norms of science, and the explicitly stated publication policies of Science.

Michael Eisen1,* and Steven Salzberg2

* To whom correspondence should be addressed. E-mail: mbeisen@berkeley.edu

1 Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
2 Center for Bioinformatics and Computational Biology, Department of Computer Science, University of Maryland, MD 20742, USA.

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The pleasure and importance of print journals???

Nature ran a weird Correspondence from Swiss organic chemist François Diederich.

Sir,

I am shocked to read in Nature News online that the American Chemical Society intends to stop all personal subscriptions to its printed journals by 2010, and to start introducing major changes this year (‘Chemistry publisher moving towards online-only journals’ http://tinyurl.com/llae53).

The attractive printed versions of Journal of the American Chemical Society, Journal of Organic Chemistry, Accounts of Chemical Research and Organic Letters provide distinct advantages in letting me browse their content (during breakfast at home, for example) and readily take in information, without the lengthy opening of individual web pages, article by article.

But I also find this decision to stop the print journals disturbing in my capacity as a board member of the German chemical society, the GDCh, and as head of the editorial board of the journal Angewandte Chemie. I believe that high-quality journals such as Nature and Science and, in chemistry, Angewandte Chemie and Journal of the American Chemical Society should continue to appear in all their published formats, including print. Otherwise, there is a risk that the quality of these prestigious journals could gradually decline to the standard of many of today’s web-only journals.

This is just plain bizarre. I can understand why someone wants printed journals to continue – I like reading things in print too. But how is it that the failure to print journals will have any effect on the journal’s quality? There are crappy web-only journals. But there are many more crappy printed journals. And I bet if you tried to do some kind of formal analysis you’d find that printing is correlated with journals sucking. But, of course, that’s just an accident too. There’s no reason to think that editorial policies are linked to the means of dissemination, or that switching the latter will affect the former.

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Um, Nature – not all flies are Drosophila

Nature Method‘s June 2009 issue focuses on “Tools for Drosophila“, complete with a cute little fly on the cover. Unfortunately, it’s not a Drosophila. Instead, it’s a stock photo of a housefly they got from some online database. You’d figure Nature, of all places, would have some Drosophila images lying around?

Nature Methods June 2009 Cover

Nature Methods June 2009 Cover

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2009 Grand Prize Winner for most egregious use of “junk DNA”

Research team finds important role for junk DNA

by Kitta MacPherson

Scientists have called it “junk DNA.” They have long been perplexed by these extensive strands of genetic material that dominate the genome but seem to lack specific functions. Why would nature force the genome to carry so much excess baggage?

[…]

http://www.princeton.edu/main/news/archive/S24/28/32C04/index.xml?section=topstories

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Unfortunate lack of links in the NY Times

I get very frustrated every time I see an article about a PLoS article in the popular press that doesn’t include a link to the article. One of our motivations for starting PLoS was to give the public access to the primary research literature, and readers of popular news accounts of one of our articles are exactly the people most likely to be interested in the article itself.

So I was particularly annoyed at a story in today’s NY Times about a recent PLoS One paper describing a recently discovered fossil primate, because the NYT story was about the authors trying to find a wider audience for their work!

It’s not like the NYT has a policy against including links. They do it sometimes. But they – and all papers – should implement a blanket policy of providing links to primary research articles that are a source for one of their stories if the article is freely available to their readers.

P.S. – The PLoS article is very cool!

[UPDATE – They added the link! Maybe someone at the Times reads my blog :-)]

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